WHAT IS PLATELET-RICH PLASMA? 

 

Platelet-Rich Plasma (PRP) is defined as an autologous concentrated preparation of platelets and their associated growth factors in a small volume of plasma [1]. Platelets are a natural source of numerous growth factors in their natural and biologically-determined ratios. Using PRP offers an innovative and promising approach to tissue regeneration.

 

 

 

PLATELET GROWTH FACTORS 

 

Upon activation, platelets release growth factors and other molecules stored in their ?(α)? granules, which are part of the natural healing process. These growth factors are signaling molecules that promote regeneration. Signaling molecules include Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor (TGF), Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), and Fibroblast Growth Factor (FGF). These molecules initiate and regulate the healing cascade -- inflammation, cell proliferation, reepithelialization, angiogenesis and tissue remodeling processes.

 

PLATELET ACTIVATION 

 

Traditionally platelets were activated by adding substances such as thrombin or calcium chloride. However, it has been postulated that in situ activation of platelets results in a slow release pattern of growth factors secretion, which may be beneficial for stimulating a continuous healing response.